Publications

  1. Hartmann J, Bajaj T, Otten J, Klengel C, Ebert T, Gellner AK, Junglas E, Hafner K, Anderzhanova EA, Tang F, Missig G, Rexrode L, Trussell DT, Li KX, Poehlmann ML, Mackert S, Geiger TM, Heinz DE, Lardenoije R, Dedic N, McCullough KM, Prochnicki T, Rhomberg T, Martinelli S, Payton A, Robinson AC, Stein V, Latz E, Carlezon WA, Hausch F, Schmidt MV, Murgatroyd C, Berretta S, Klengel T, Pantazopoulos H, Ressler KJ, Gassen NC. SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration. Nature Communications. 2024 Mar 25;15(1):2635. doi: 10.1038/s41467-024-46953-x. PubMed PMID: 38528004; PubMed Central PMCID: PMC10963788.

  2. Ke S, Hartmann J, Ressler KJ, Liu YY, Koenen KC. The emerging role of the gut microbiome in posttraumatic stress disorder. Brain Behavior and Immunity. 2023 Nov;114:360-370. doi: 10.1016/j.bbi.2023.09.005. Epub 2023 Sep 7. Review. PubMed PMID: 37689277; PubMed Central PMCID: PMC10591863.

  3. Chatzinakos C, Pernia CD, Morrison FG, Iatrou A, McCullough KM, Schuler H, Snijders C, Bajaj T, DiPietro CP, Soliva Estruch M, Gassen NC, Anastasopoulos C, Bharadwaj RA, Bowlby BC, Hartmann J, Maihofer AX, Nievergelt CM, Ressler NM, Wolf EJ, Carlezon WA Jr, Krystal JH, Kleinman JE, Girgenti MJ, Huber BR, Kellis M, Logue MW, Miller MW, Ressler KJ, Daskalakis NP. Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response. Am Journal of Psychiatry. 2023 Oct 1;180(10):739-754. doi: 10.1176/appi.ajp.20220478. Epub 2023 Jul 26. PubMed PMID: 37491937.

  4. Bordes J, Miranda L, Reinhardt M, Narayan S, Hartmann J, Newman EL, Brix LM, van Doeselaar L, Engelhardt C, Dillmann L, Mitra S, Ressler KJ, Pütz B, Agakov F, Müller-Myhsok B, Schmidt MV. Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress. Nature Communications. 2023 Jul 18;14(1):4319. doi: 10.1038/s41467-023-40040-3. PubMed PMID: 37463994; PubMed Central PMCID: PMC10354203.

  5. McCullough KM, Katrinli S, Hartmann J, Lori A, Klengel C, Missig G, Klengel T, Langford NA, Newman EL, Anderson KJ, Smith AK, Carroll FI, Ressler KJ, Carlezon WA Jr. Blood levels of T-Cell Receptor Excision Circles (TRECs) provide an index of exposure to traumatic stress in mice and humans. Translational Psychiatry. 2022 Oct 3;12(1):423. doi: 10.1038/s41398-022-02159-7. PubMed PMID: 36192377; PubMed Central PMCID: PMC9530209.

  6. Martinelli S, Anderzhanova EA, Bajaj T, Wiechmann S, Dethloff F, Weckmann K, Heinz DE, Ebert T, Hartmann J, Geiger TM, Döngi M, Hafner K, Pöhlmann ML, Jollans L, Philipsen A, Schmidt SV, Schmidt U, Maccarrone G, Stein V, Hausch F, Turck CW, Schmidt MV, Gellner AK, Kuster B, Gassen NC. Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nature Communications. 2021 Jul 30;12(1):4643. doi: 10.1038/s41467-021-24810-5. PubMed PMID: 34330919; PubMed Central PMCID: PMC8324795.

  7. Häusl AS, Brix LM, Hartmann J, Pöhlmann ML, Lopez JP, Menegaz D, Brivio E, Engelhardt C, Roeh S, Bajaj T, Rudolph L, Stoffel R, Hafner K, Goss HM, Reul JMHM, Deussing JM, Eder M, Ressler KJ, Gassen NC, Chen A, Schmidt MV. The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice. Molecular Psychiatry. 2021 Jul;26(7):3060-3076. doi: 10.1038/s41380-021-01044-x. Epub 2021 Mar 1. PubMed PMID: 33649453; PubMed Central PMCID: PMC8505251.

  8. McCullough KM, Missig G, Robble MA, Foilb AR, Wells AM, Hartmann J, Anderson KJ, Neve RL, Nestler EJ, Ressler KJ, Carlezon WA Jr.Nucleus Accumbens Medium Spiny Neuron Subtypes Differentially Regulate Stress-Associated Alterations in Sleep Architecture. Biological Psychiatry. 2021 Jun 15;89(12):1138-1149. doi: 10.1016/j.biopsych.2020.12.030. Epub 2021 Jan 13. PubMed PMID: 33715826; PubMed Central PMCID: PMC8178228.

  9. Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, McCullough KM, Lardenoije R, Joëls M, Meijer OC, McCann KE, Dudek SM, Sarabdjitsingh RA, Daskalakis NP, Klengel T, Gassen NC, Schmidt MV, Ressler KJ. Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5. Cell Reports. 2021 Jun 1;35(9):109185. doi: 10.1016/j.celrep.2021.109185. PubMed PMID: 34077736; PubMed Central PMCID: PMC8244946.

  10. McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, Carlezon WA Jr, Daskalakis NP, Ressler KJ. Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nature Communications. 2020 Oct 14;11(1):5180. doi: 10.1038/s41467-020-18985-6. PubMed PMID: 33057013; PubMed Central PMCID: PMC7560654.

  11. Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH, Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Reports. 2020 Jun 2;31(9):107716. doi: 10.1016/j.celrep.2020.107716. PubMed PMID: 32492425; PubMed Central PMCID: PMC7359754.

  12. Dedic N, Kühne C, Gomes KS, Hartmann J, Ressler KJ, Schmidt MV, Deussing JM. Deletion of CRH From GABAergic Forebrain Neurons Promotes Stress Resilience and Dampens Stress-Induced Changes in Neuronal Activity. Fronties in Neuroscience. 2019;13:986. doi: 10.3389/fnins.2019.00986. eCollection 2019. PubMed PMID: 31619956; PubMed Central PMCID: PMC6763571.

  13. van Weert LTCM, Buurstede JC, Sips HCM, Vettorazzi S, Mol IM, Hartmann J, Prekovic S, Zwart W, Schmidt MV, Roozendaal B, Tuckermann JP, Sarabdjitsingh RA, Meijer OC. Identification of mineralocorticoid receptor target genes in the mouse hippocampus. Journal of Neuroendocrinology. 2019 Aug;31(8):e12735. doi: 10.1111/jne.12735. Epub 2019 Jun 14. PubMed PMID: 31121060; PubMed Central PMCID: PMC6771480.

  14. Maddox SA, Hartmann J, Ross RA, Ressler KJ. Deconstructing the Gestalt: Mechanisms of Fear, Threat, and Trauma Memory Encoding. Neuron. 2019 Apr 3;102(1):60-74. doi: 10.1016/j.neuron.2019.03.017. Review. PubMed PMID: 30946827; PubMed Central PMCID: PMC6450587.

  15. Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM. Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nature Neuroscience. 2018 Jun;21(6):803-807. doi: 10.1038/s41593-018-0151-z. Epub 2018 May 21. PubMed PMID: 29786085; PubMed Central PMCID: PMC6951443.

  16. Dedic N, Pöhlmann ML, Richter JS, Mehta D, Czamara D, Metzger MW, Dine J, Bedenk BT, Hartmann J, Wagner KV, Jurik A, Almli LM, Lori A, Moosmang S, Hofmann F, Wotjak CT, Rammes G, Eder M, Chen A, Ressler KJ, Wurst W, Schmidt MV, Binder EB, Deussing JM. Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood. Molecular Psychiatry.2018 Mar;23(3):533-543. doi: 10.1038/mp.2017.133. Epub 2017 Jul 11. PubMed PMID: 28696432; PubMed Central PMCID: PMC5822460.

  17. McCullough KM, Morrison FG, Hartmann J, Carlezon WA Jr, Ressler KJ. Quantified Coexpression Analysis of Central Amygdala Subpopulations. eNeuro. 2018 Jan-Feb;5(1). doi: 10.1523/ENEURO.0010-18.2018. eCollection 2018 Jan-Feb. PubMed PMID: 29445764; PubMed Central PMCID: PMC5810038.

  18. Santarelli S, Zimmermann C, Kalideris G, Lesuis SL, Arloth J, Uribe A, Dournes C, Balsevich G, Hartmann J, Masana M, Binder EB, Spengler D, Schmidt MV. An adverse early life environment can enhance stress resilience in adulthood. Psychoneuroendocrinology. 2017 Apr;78:213-221. doi: 10.1016/j.psyneuen.2017.01.021. Epub 2017 Feb 7. PubMed PMID: 28219813.

  19. Hartmann J, Dedic N, Pöhlmann ML, Häusl A, Karst H, Engelhardt C, Westerholz S, Wagner KV, Labermaier C, Hoeijmakers L, Kertokarijo M, Chen A, Joëls M, Deussing JM, Schmidt MV. Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor. Molecular Psychiatry. 2017 Mar;22(3):466-475. doi: 10.1038/mp.2016.87. Epub 2016 May 31. PubMed PMID: 27240530.

  20. Gassen NC, Hartmann J, Zannas AS, Kretzschmar A, Zschocke J, Maccarrone G, Hafner K, Zellner A, Kollmannsberger LK, Wagner KV, Mehta D, Kloiber S, Turck CW, Lucae S, Chrousos GP, Holsboer F, Binder EB, Ising M, Schmidt MV, Rein T. FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. Molecular Psychiatry. 2016 Feb;21(2):277-89. doi: 10.1038/mp.2015.38. Epub 2015 Apr 7. PubMed PMID: 25849320.

  21. Santarelli S, Wagner KV, Labermaier C, Uribe A, Dournes C, Balsevich G, Hartmann J, Masana M, Holsboer F, Chen A, Müller MB, Schmidt MV. SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Stress. 2016;19(1):83-90. doi: 10.3109/10253890.2015.1105211. Epub 2015 Nov 20. PubMed PMID: 26585320.

  22. Gassen NC, Fries GR, Zannas AS, Hartmann J, Zschocke J, Hafner K, Carrillo-Roa T, Steinbacher J, Preißinger SN, Hoeijmakers L, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rüegg J, Rein T. Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. Science Signaling. 2015 Nov 24;8(404):ra119. doi: 10.1126/scisignal.aac7695. PubMed PMID: 26602018.

  23. Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S, Namendorf C, Gerlach T, Uhr M, Chen A, Deussing JM, Holsboer F, Hausch F, Schmidt MV. Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties. Journal of Neuroscience. 2015 Jun 17;35(24):9007-16. doi: 10.1523/JNEUROSCI.4024-14.2015. PubMed PMID: 26085626; PubMed Central PMCID: PMC6605153.

  24. Wagner KV, Hartmann J, Labermaier C, Häusl AS, Zhao G, Harbich D, Schmid B, Wang XD, Santarelli S, Kohl C, Gassen NC, Matosin N, Schieven M, Webhofer C, Turck CW, Lindemann L, Jaschke G, Wettstein JG, Rein T, Müller MB, Schmidt MV. Homer1/mGluR5 activity moderates vulnerability to chronic social stress. Neuropsychopharmacology. 2015 Mar 13;40(5):1222-33. doi: 10.1038/npp.2014.308. PubMed PMID: 25409593; PubMed Central PMCID: PMC4367467.

  25. Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L. A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies. Psychoneuroendocrinology. 2015 Feb;52:43-58. doi: 10.1016/j.psyneuen.2014.11.005. Epub 2014 Nov 11. PubMed PMID: 25459892.

  26. Gassen NC, Hartmann J, Schmidt MV, Rein T. FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action. Autophagy. 2015;11(3):578-80. doi: 10.1080/15548627.2015.1017224. PubMed PMID: 25714272; PubMed Central PMCID: PMC4502647.

  27. Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Rühter G, Uhr M, Schmidt MV, Touma C, Bracher A, Hausch F. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nature Chemical Biology. 2015 Jan;11(1):33-7. doi: 10.1038/nchembio.1699. Epub 2014 Dec 1. PubMed PMID: 25436518.

  28. Gassen NC*, Hartmann J*, Zschocke J, Stepan J, Hafner K, Zellner A, Kirmeier T, Kollmannsberger L, Wagner KV, Dedic N, Balsevich G, Deussing JM, Kloiber S, Lucae S, Holsboer F, Eder M, Uhr M, Ising M, Schmidt MV, Rein T. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. PLoS Medicine. 2014 Nov;11(11):e1001755. doi: 10.1371/journal.pmed.1001755. eCollection 2014 Nov. PubMed PMID: 25386878; PubMed Central PMCID: PMC4227651.

  29. Masana M, Su YA, Liebl C, Wang XD, Jansen L, Westerholz S, Wagner KV, Labermaier C, Scharf SH, Santarelli S, Hartmann J, Schmidt MV, Rein T, Müller MB. The stress-inducible actin-interacting protein DRR1 shapes social behavior. Psychoneuroendocrinology. 2014 Oct;48:98-110. doi: 10.1016/j.psyneuen.2014.06.009. Epub 2014 Jun 19. PubMed PMID: 24998413.

  30. Labermaier C, Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, Jones KA, Müller MB, Uhr M, Holsboer F, Binder EB, Schmidt MV. A polymorphism in the Crhr1 gene determines stress vulnerability in male mice. Endocrinology. 2014 Jul;155(7):2500-10. doi: 10.1210/en.2013-1986. Epub 2014 Apr 28. PubMed PMID: 24773341.

  31. Balsevich G, Uribe A, Wagner KV, Hartmann J, Santarelli S, Labermaier C, Schmidt MV. Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51. Journal of Endocrinology. 2014 Jul;222(1):15-26. doi: 10.1530/JOE-14-0129. Epub 2014 Apr 29. PubMed PMID: 24781256.

  32. Santarelli S, Lesuis SL, Wang XD, Wagner KV, Hartmann J, Labermaier C, Scharf SH, Müller MB, Holsboer F, Schmidt MV. Evidence supporting the match/mismatch hypothesis of psychiatric disorders. European Neuropsychopharmacology. 2014 Jun;24(6):907-18. doi: 10.1016/j.euroneuro.2014.02.002. Epub 2014 Feb 15. PubMed PMID: 24589292.

  33. Hoeijmakers L, Harbich D, Schmid B, Lucassen PJ, Wagner KV, Schmidt MV, Hartmann J. Depletion of FKBP51 in female mice shapes HPA axis activity. PLoS One. 2014;9(4):e95796. doi: 10.1371/journal.pone.0095796. eCollection 2014. PubMed PMID: 24759731; PubMed Central PMCID: PMC3997427.

  34. Albu S, Romanowski CP, Letizia Curzi M, Jakubcakova V, Flachskamm C, Gassen NC, Hartmann J, Schmidt MV, Schmidt U, Rein T, Holsboer F, Hausch F, Paez-Pereda M, Kimura M. Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice. Journal of Sleep Research. 2014 Apr;23(2):176-85. doi: 10.1111/jsr.12112. Epub 2013 Dec 5. PubMed PMID: 24354785.

  35. Wagner KV, Häusl AS, Pöhlmann ML, Hartmann J, Labermaier C, Müller MB, Schmidt MV. Hippocampal Homer1 levels influence motivational behavior in an operant conditioning task. PLoS One. 2014;9(1):e85975. doi: 10.1371/journal.pone.0085975. eCollection 2014. PubMed PMID: 24465821; PubMed Central PMCID: PMC3897610.

  36. Kollmannsberger LK, Gassen NC, Bultmann A, Hartmann J, Weber P, Schmidt MV, Rein T. Increased glyoxalase-1 levels in Fkbp5 knockout mice caused by glyoxalase-1 gene duplication. G3 (Bethesda). 2013 Aug 7;3(8):1311-3. doi: 10.1534/g3.113.006445. PubMed PMID: 23733890; PubMed Central PMCID: PMC3737170.

  37. Wang XD, Su YA, Wagner KV, Avrabos C, Scharf SH, Hartmann J, Wolf M, Liebl C, Kühne C, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV. Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nature Neuroscience. 2013 Jun;16(6):706-13. doi: 10.1038/nn.3395. Epub 2013 May 5. PubMed PMID: 23644483.

  38. Wagner KV, Hartmann J, Mangold K, Wang XD, Labermaier C, Liebl C, Wolf M, Gassen NC, Holsboer F, Rein T, Müller MB, Schmidt MV.Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus. Journal of Neuroscience. 2013 Feb 27;33(9):3857-64. doi: 10.1523/JNEUROSCI.4333-12.2013. PubMed PMID: 23447597; PubMed Central PMCID: PMC6619309.

  39. Hartmann J, Wagner KV, Dedic N, Marinescu D, Scharf SH, Wang XD, Deussing JM, Hausch F, Rein T, Schmidt U, Holsboer F, Müller MB, Schmidt MV. Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice. Psychoneuroendocrinology. 2012 Dec;37(12):2009-21. doi: 10.1016/j.psyneuen.2012.04.017. Epub 2012 May 27. PubMed PMID: 22641006.

  40. Wagner KV, Marinescu D, Hartmann J, Wang XD, Labermaier C, Scharf SH, Liebl C, Uhr M, Holsboer F, Müller MB, Schmidt MV. Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment. Neuropsychopharmacology. 2012 Dec;37(13):2797-808. doi: 10.1038/npp.2012.150. Epub 2012 Aug 8. PubMed PMID: 22871917; PubMed Central PMCID: PMC3499723.

  41. Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, Schmidt MV. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. 2012 Jan;62(1):332-9. doi: 10.1016/j.neuropharm.2011.07.041. Epub 2011 Aug 4. PubMed PMID: 21839098.

  42. Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U, Rein T. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biological Psychiatry. 2011 Nov 15;70(10):928-36. doi: 10.1016/j.biopsych.2011.07.023. Epub 2011 Sep 10. PubMed PMID: 21907973.

  43. Schmidt MV, Liebl C, Sterlemann V, Ganea K, Hartmann J, Harbich D, Alam S, Müller MB. Neuropeptide Y mediates the initial hypothalamic-pituitary-adrenal response to maternal separation in the neonatal mouse. Journal of Endocrinology. 2008 May;197(2):421-7. doi: 10.1677/JOE-07-0634. PubMed PMID: 18434372.